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黛比（瑞茜·威瑟斯彭饰）和彼得（阿什顿·库彻饰）是最好的朋友，但性格却截然不同。黛比渴望和儿子在洛杉矶过着普通生活；彼得则在不断变化的纽约奋力拼搏。他们决定交换房子并体验彼此的生活，一周后，他们发现自己向往的一切可能并不是内心真正需要的东西。。The Cold War has ended, and the Russian government has decided get rid of a deadly bioweapon sample by returning it to the United States, from whom it had been stolen. Officer Hendricks has been assigned to pick up the virus sample and escort it back to America via submarine. Along the way, however, a gang of terrorists hijack the sub in an attempt to launch a bioweapon attack ...。